Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins-Reference-Cited by-同舟云学术

Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins

Published:2023-03-30 Issue:7 Volume:66 Page:4703-4733
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ng Yuen Lam Dora¹,Bricelj Aleša²,Jansen Jacqueline A.¹,Murgai Arunima¹³,Peter Kirsten¹,Donovan Katherine A.⁴⁵^ORCID,Gütschow Michael⁶^ORCID,Krönke Jan¹³,Steinebach Christian⁶^ORCID,Sosič Izidor²^ORCID

Affiliation:

1. Department of Hematology, Oncology and Cancer Immunology, Charité─Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, D-12203 Berlin, Germany

2. Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, SI-1000 Ljubljana, Slovenia

3. German Cancer Consortium (DKTK) Partner Site Berlin and German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany

4. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States

5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States

6. Phamaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01817

Reference69 articles.

1. Prey for the Proteasome: Targeted Protein Degradation—A Medicinal Chemist's Perspective

2. PROTACs: An Emerging Therapeutic Modality in Precision Medicine

3. Targeted protein degradation and drug discovery

4. Targeted protein degraders crowd into the clinic

5. PROTACs: past, present and future

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