Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins

Author:

Ng Yuen Lam Dora1,Bricelj Aleša2,Jansen Jacqueline A.1,Murgai Arunima13,Peter Kirsten1,Donovan Katherine A.45ORCID,Gütschow Michael6ORCID,Krönke Jan13,Steinebach Christian6ORCID,Sosič Izidor2ORCID

Affiliation:

1. Department of Hematology, Oncology and Cancer Immunology, Charité─Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, D-12203 Berlin, Germany

2. Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, SI-1000 Ljubljana, Slovenia

3. German Cancer Consortium (DKTK) Partner Site Berlin and German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany

4. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States

5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States

6. Phamaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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