Discovery of Nanomolar DCAF1 Small Molecule Ligands

Author:

Li Alice Shi Ming123ORCID,Kimani Serah14,Wilson Brian2,Noureldin Mahmoud23,González-Álvarez Héctor23,Mamai Ahmed2,Hoffer Laurent2,Guilinger John P.5,Zhang Ying5,von Rechenberg Moritz6,Disch Jeremy S.6ORCID,Mulhern Christopher J.6,Slakman Belinda L.6,Cuozzo John W.6ORCID,Dong Aiping1,Poda Gennady27,Mohammed Mohammed2,Saraon Punit2,Mittal Manish8,Modh Pratik8,Rathod Vaibhavi8,Patel Bhashant8,Ackloo Suzanne1,Santhakumar Vijayaratnam1ORCID,Szewczyk Magdalena M1,Barsyte-Lovejoy Dalia13,Arrowsmith Cheryl H.149ORCID,Marcellus Richard2,Guié Marie-Aude5,Keefe Anthony D.5,Brown Peter J.1ORCID,Halabelian Levon13ORCID,Al-awar Rima2310,Vedadi Masoud123ORCID

Affiliation:

1. Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada

2. Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada

3. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

4. Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2C1, Canada

5. X-Chem Inc., Waltham, Massachusetts 02453, United States

6. Relay Therapeutics, Cambridge, Massachusetts 02139, United States

7. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada

8. Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat 382213, India

9. Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada

10. Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada

Funder

National Institute of General Medical Sciences

Government of Ontario

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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