Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer

Published:2022-09-07 Issue:18 Volume:65 Page:12460-12481
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Ao¹²,Luo Xianggang¹²,Wang Yawan³,Meng Xin¹,Lu Zhengyu¹²,Yang Yushe¹²^ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

2. School of Pharmacy, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China

3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01164

Reference51 articles.

1. Cancer statistics, 2000

2. Drug discovery in advanced prostate cancer: translating biology into therapy

3. Novel, potent anti-androgens of therapeutic potential: recent advances and promising developments

4. Androgen receptor action in hormone-dependent and recurrent prostate cancer

5. Understanding and overcoming the mechanisms of primary and acquired resistance to abiraterone and enzalutamide in castration resistant prostate cancer

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