Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity-Reference-Cited by-同舟云学术

Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity

Published:2022-08-16 Issue:16 Volume:65 Page:11340-11364
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Musella Simona¹,Carotenuto Lidia²,Iraci Nunzio³^ORCID,Baroli Giulia²,Ciaglia Tania¹,Nappi Piera²,Basilicata Manuela Giovanna¹,Salviati Emanuela¹,Barrese Vincenzo²,Vestuto Vincenzo¹,Pignataro Giuseppe²,Pepe Giacomo¹^ORCID,Sommella Eduardo¹,Di Sarno Veronica¹,Manfra Michele⁴,Campiglia Pietro¹^ORCID,Gomez-Monterrey Isabel⁵^ORCID,Bertamino Alessia¹^ORCID,Taglialatela Maurizio²^ORCID,Ostacolo Carmine⁵^ORCID,Miceli Francesco²

Affiliation:

1. Department of Pharmacy, University of Salerno, Via G. Paolo II 132, Fisciano 84084, Salerno, Italy

2. Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, Naples 80131, Italy

3. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina, Viale Ferdinando Stagno d’Alcontres 31, Messina 98166, Italy

4. Department of Science, University of Basilicata, Via dell’Ateneo Lucano 10, Potenza 85100, Italy

5. Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, Naples 80131, Italy

Funder

Ministero dell?Istruzione, dell?Universit? e della Ricerca

Universit? degli Studi di Napoli Federico II

Compagnia di San Paolo

Ministero della Salute

H2020 Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine