Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes-Reference-Cited by-同舟云学术

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Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes

Published:2023-02-07 Issue:4 Volume:66 Page:2622-2645
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Saint-Dizier François¹,Matthews Thomas P.¹^ORCID,Gregson Aaron M.¹^ORCID,Prevet Hugues¹,McHardy Tatiana¹,Colombano Giampiero¹,Saville Harry¹,Rowlands Martin¹,Ewens Caroline¹,McAndrew P. Craig¹^ORCID,Tomlin Kathy¹,Guillotin Delphine¹^ORCID,Mak Grace Wing-Yan¹^ORCID,Drosopoulos Konstantinos²,Poursaitidis Ioannis¹^ORCID,Burke Rosemary¹,van Montfort Rob¹³,Linardopoulos Spiros¹²,Collins Ian¹^ORCID

Affiliation:

1. Centre for Cancer Drug Discovery, Division of Cancer Therapeutics, The Institute of Cancer Research, London SW7 3RP, U.K.

2. Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW7 3RP, U.K.

3. Division of Structural Biology, The Institute of Cancer Research, London SW7 3RP, U.K.

Funder

Breast Cancer Now

Merck KGaA

Institute of Cancer Research

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01591

Reference42 articles.

1. C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma

2. Origins of reversed directionality in the ncd molecular motor.

3. The Kinesin-Related Protein, Hset, Opposes the Activity of Eg5 and Cross-Links Microtubules in the Mammalian Mitotic Spindle

4. Centrosome biogenesis and function: centrosomics brings new understanding

5. A mechanism linking extra centrosomes to chromosomal instability

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