Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase-Reference-Cited by-全球学者库

Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase

Published:2022-12-16 Issue:1 Volume:66 Page:220-234
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhan Zhengsheng¹,Ji Yinchun²,Su Haixia³,Fang Chen¹⁴,Peng Xia²⁵,Liu Qiufeng³,Dai Yang²,Lin Dongze²,Xu Yechun³⁵⁶^ORCID,Ai Jing²⁵⁷,Duan Wenhu¹⁴⁵^ORCID

Affiliation:

1. Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China

2. Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, P. R. China

3. CAS Key Laboratory of Receptor Research and Drug Discovery and Design Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, P. R. China

4. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, P. R. China

5. University of Chinese Academy of Sciences, Beijing 100049, P. R. China

6. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, P. R. China

7. Hangzhou Institute for Advanced Study (UCAS), Hangzhou 310024, P. R. China

Funder

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Chinese Academy of Sciences

Lingang Laboratory

Shanghai Institute of Materia Medica

Shanghai Municipal Commission of Health and Family Planning

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine