Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid <i>α</i>/<i>β</i>-Hydrolase Domain 6 (ABHD6)-Reference-Cited by-同舟云学术

Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β-Hydrolase Domain 6 (ABHD6)

Published:2022-12-14 Issue:1 Volume:66 Page:538-552
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mardon Karine^ORCID,Patel Jayendra Z.¹,Savinainen Juha R.²,Stimson Damion H. R.,Oyagawa Caitlin R. M.³,Grimsey Natasha L.³^ORCID,Migotto Mary-anne,Njiru Grace F. M.,Hamilton Brett R.⁴^ORCID,Cowin Gary,Yli-Kauhaluoma Jari¹^ORCID,Vanduffel Wim⁵,Blakey Idriss⁶^ORCID,Bhalla Rajiv,Cawthorne Christopher⁷^ORCID,Celen Sofie⁸^ORCID,Bormans Guy⁸^ORCID,Thurecht Kristofer J⁶^ORCID,Ahamed Muneer⁶^ORCID

Affiliation:

1. Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, FI-00014 Helsinki, Finland

2. Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland

3. Department of Pharmacology and Clinical Pharmacology, Centre for Brain Research, and Maurice Wilkins Centre for Molecular Biodiscovery, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand

4. Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane 4072, Australia

5. Laboratory for Neuro-and Psychophysiology, Department of Neurosciences, & Leuven Brain Institute, KU Leuven, Leuven 3000, Belgium

6. ARC Centre for Innovation in Biomedical Imaging Technology, Centre for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia

7. Nuclear Medicine and Molecular Imaging & MoSAIC, Department of Imaging and Pathology, KU Leuven, Leuven 3000, Belgium

8. Laboratory for Radiopharmaceutical Research, Department of Pharmacy and Pharmacological Sciences, KU Leuven, Leuven 3000, Belgium

Funder

National Health and Medical Research Council

Australian Research Council

Fonds Wetenschappelijk Onderzoek

Suomen Akatemia

University of Queensland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01485

Reference60 articles.

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3. A Guide to Targeting the Endocannabinoid System in Drug Design

4. Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications

5. Advances in mass spectrometry imaging enabling observation of localised lipid biochemistry within tissues

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