Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity-Reference-Cited by-同舟云学术

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

Published:2022-09-15 Issue:19 Volume:65 Page:13343-13364
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gao Shenghua¹²,Sylvester Katharina³,Song Letian¹,Claff Tobias³,Jing Lanlan¹,Woodson Molly⁴⁵,Weiße Renato H.⁶^ORCID,Cheng Yusen¹,Schäkel Laura³,Petry Marvin³,Gütschow Michael³^ORCID,Schiedel Anke C.³,Sträter Norbert⁶^ORCID,Kang Dongwei¹^ORCID,Xu Shujing¹,Toth Karoly⁴⁵,Tavis John⁴⁵^ORCID,Tollefson Ann E.⁴⁵,Müller Christa E.³^ORCID,Liu Xinyong¹^ORCID,Zhan Peng¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji’nan 250012, China

2. Shenzhen Research Institute of Shandong University, A301 Virtual University Park in South District of Shenzhen, Guangdong 518057, P. R. China

3. PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53113, Germany

4. Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri 63103, United States

5. Saint Louis University Institute for Drug and Biotherapeutic Innovation, St. Louis, Missouri 63103, United States

6. Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, Leipzig 04103, Germany

Funder

Guangdong Science and Technology Department

China Postdoctoral Science Foundation

Natural Science Foundation of Shandong Province

Volkswagen Foundation

Science Foundation for Outstanding Young Scholars of Shandong Province

Foreign Cultural and Educational Experts Project

Publisher

American Chemical Society (ACS)