Discovery of 2-Methyl-2-(4-(2-methyl-8-(1H-pyrrolo[2,3-b]pyridin-6-yl)-1H-naphtho[1,2-d]imidazol-1-yl)phenyl)propanenitrile as a Novel PI3K/mTOR Inhibitor with Enhanced Antitumor Efficacy In Vitro and In Vivo

Author:

Yang Jie123,Liu Yuanyuan1,Lan Suke4,Yu Su1,Ma Xinyu1,Luo Dan1,Shan Huifang1,Zhong Xinxin1,Yan Guoyi1,Li Rui1ORCID

Affiliation:

1. State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu 610041, China

2. Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, China

3. Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China

4. College of Chemistry & Environment Protection Engineering, Southwest Minzu University, Chengdu 610041, China

Funder

China Postdoctoral Science Foundation

Chengdu Science and Technology Bureau

Department of Science and Technology of Sichuan Province

National Natural Science Foundation of China

Health Department of Sichuan Province

Medical Engineering Cross Foundation of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital

Youth Talent Foundation of Sichuan Provincial People's Hospital

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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