Discovery of Hexahydrofuro[3,2-<i>b</i>]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant-Reference-Cited by-同舟云学术

Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant

Published:2022-07-21 Issue:15 Volume:65 Page:10674-10690
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Shan¹^ORCID,Si Hongfei¹,Song Xiaojuan²,Lei Chong³,He Xiaoqiang¹,Wang Jie¹,Liu Yiling¹,Zhou Yang¹^ORCID,Song Jian-Guo¹^ORCID,Peng Lijie¹,Tang Xia¹,Chan Shingpan⁴,Ren Xiaomei¹,Tu Zhengchao²,Li Zhengqiu¹^ORCID,Wang Zhen³^ORCID,Zhang Zhang¹,Ding Ke¹³⁵⁶^ORCID

Affiliation:

1. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China

2. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou 510530, China

3. State Key Laboratory of Bioorganic Chemistry and Natural Products, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Road, Shanghai 200032, China

4. Guangzhou Lixin Pharmaceuticals, Guangzhou 510530, China

5. The First Affiliated Hospital (Huaqiao Hospital), Jinan University, #601 Huangpu Avenue West, Guangzhou 510632, China

6. Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, Zhejiang, China

Funder

Shenzhen Bay Laboratory

Government of Guangdong Province

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry

Publisher

American Chemical Society (ACS)

Subject