Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss-Reference-Cited by-同舟云学术

Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss

Published:2023-02-19 Issue:5 Volume:66 Page:3195-3211
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Garnsey Michelle R.¹^ORCID,Smith Aaron C.²^ORCID,Polivkova Jana²,Arons Autumn L.¹,Bai Guoyun²,Blakemore Caroline²^ORCID,Boehm Markus¹^ORCID,Buzon Leanne M.²,Campion Sarah N.²,Cerny Matthew²,Chang Shiao-Chi¹,Coffman Karen²,Farley Kathleen A.²^ORCID,Fonseca Kari R.¹,Ford Kristen K.²,Garren Jeonifer¹,Kong Jimmy X.¹,Koos Martin R. M.²^ORCID,Kung Daniel W.²^ORCID,Lian Yajing²,Li Monica M.¹,Li Qifang²,Martinez-Alsina Luis A.²,O’Connor Rebecca²,Ogilvie Kevin²,Omoto Kiyoyuki¹,Raymer Brian¹,Reese Matthew R.²,Ryder Tim²,Samp Lacey²,Stevens Kimberly A.²,Widlicka Daniel W.²^ORCID,Yang Qingyi¹^ORCID,Zhu Kaicheng²,Fortin Jean-Philippe¹,Sammons Matthew F.¹^ORCID

Affiliation:

1. Pfizer, Incorporated, Cambridge, Massachusetts 02139, United States

2. Pfizer, Incorporated, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c02012

Reference64 articles.

1. The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

2. AgRP(83–132) Acts as an Inverse Agonist on the Human-Melanocortin-4 Receptor