Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5

Author:

Suenkel Benjamin1,Valente Sergio2ORCID,Zwergel Clemens2ORCID,Weiss Sandra1,Di Bello Elisabetta2,Fioravanti Rossella2,Aventaggiato Michele3,Amorim João A.456,Garg Neha6,Kumar Surinder7,Lombard David B.78,Hu Tuo9,Singh Pankaj K.91011,Tafani Marco3,Palmeira Carlos M.45,Sinclair David6,Mai Antonello2ORCID,Steegborn Clemens1ORCID

Affiliation:

1. Department of Biochemistry, University of Bayreuth, 95440 Bayreuth, Germany

2. Department of Drug Chemistry and Technologies, Sapienza University of Rome, and Pasteur Institute, Cenci-Bolognetti Foundation, 00185 Rome, Italy

3. Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy

4. Department of Life Sciences, University of Coimbra, 3004-504 Coimbra, Portugal

5. Center for Neurosciences and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal

6. Genetics Department, Blavatnik Institute, Glenn Center for Biology of Aging Research, Harvard Medical School, Boston, Massachusetts 02115, United States

7. Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109-2800, United States

8. Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109-2800, United States

9. The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-7696, United States

10. Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198-7696, United States

11. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-7696, United States

Funder

National Institute of Environmental Health Sciences

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Ministero dell?Istruzione, dell?Universit? e della Ricerca

European Regional Development Fund

Doktor Robert Pfleger-Stiftung

Associazione Italiana per la Ricerca sul Cancro

U.S. Department of Defense

National Institute of General Medical Sciences

Funda??o para a Ci?ncia e a Tecnologia

Oberfrankenstiftung

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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