Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP–Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis-Reference-Cited by-同舟云学术

Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP–Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis

Published:2022-06-13 Issue:16 Volume:65 Page:11010-11033
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Peng Ting¹²³,He Yujiao¹²,Wang Tao¹^ORCID,Yu Jialing¹³,Ma Xiaofang⁴,Zhou Zongyuan¹³,Sheng Yuwen¹³,Li Lingyu¹³,Peng Huipan¹,Li Sheng¹,Zou Jiawei¹,Yuan Yi¹,Zhao Yongyun¹,Shi Hailong¹³,Li Fu¹^ORCID,Liu Wanli⁵,Hu Kaifeng⁴^ORCID,Lu Xiaoxia¹^ORCID,Zhang Guolin¹⁶,Wang Fei¹⁶^ORCID

Affiliation:

1. Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China

2. Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

5. Ministry of Education Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing 100084, China

6. Xiongan Institute of Innovation, Chinese Academy of Sciences, Hebei 071700, China

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00189

Reference66 articles.