Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials

Author:

Stoye Alexander1,Juillard Annette2,Tang Arthur H.1,Legac Jennifer3,Gut Jiri3,White Karen L.4,Charman Susan A.4,Rosenthal Philip J.3,Grau Georges E. R.2,Hunt Nicholas H.2,Payne Richard J.1ORCID

Affiliation:

1. School of Chemistry, Building F11, The University of Sydney, Sydney, New South Wales 2006, Australia

2. School of Medical Sciences, Sydney Medical School, Building K25, The University of Sydney, Medical Foundation, Sydney, New South Wales 2006, Australia

3. Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, United States

4. Centre for Drug Candidate Optimisation, Monash University, Victoria 3052, Australia

Funder

National Health and Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference41 articles.

1. Malaria

2. World Heath Organization. The World Malaria Report. Nov 2018, pp 1 200. https://www.who.int/malaria/publications/world-malaria-report-2018/en/.

3. Artemisinin Action and Resistance in Plasmodium falciparum

4. The re-emergence of natural products for drug discovery in the genomics era

5. Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

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