2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-Protein Coupled Receptors. The Whole Is Greater Than the Sum of Its Parts
Author:
Affiliation:
1. Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse—Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States
Funder
National Institute on Drug Abuse
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01105
Reference195 articles.
1. Narcotic antagonistic potency of bivalent ligands which contain .beta.-naltrexamine. Evidence for simultaneous occupation of proximal recognition sites
2. Opioid agonist and antagonist bivalent ligands as receptor probes
3. Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers
4. Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors
5. Synthesis and biological activity of analogs of .beta.-chlornaltrexamine and .beta.-funaltrexamine at opioid receptors
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