Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain-Reference-Cited by-同舟云学术

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain

Published:2019-04-03 Issue:8 Volume:62 Page:4091-4109
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

McKerrall Steven J.¹^ORCID,Nguyen Teresa¹,Lai Kwong Wah²,Bergeron Philippe¹,Deng Lunbin¹,DiPasquale Antonio¹,Chang Jae H.¹,Chen Jun¹,Chernov-Rogan Tania¹,Hackos David H.¹,Maher Jonathan¹,Ortwine Daniel F.¹,Pang Jodie¹,Payandeh Jian¹,Proctor William R.¹,Shields Shannon D.¹,Vogt Jennifer¹,Ji Pengfei²,Liu Wenfeng²,Ballini Elisa³,Schumann Lilia³,Tarozzo Glauco³,Bankar Girish⁴,Chowdhury Sultan⁴,Hasan Abid⁴,Johnson J. P.⁴,Khakh Kuldip⁴,Lin Sophia⁴,Cohen Charles J.⁴,Dehnhardt Christoph M.⁴^ORCID,Safina Brian S.¹,Sutherlin Daniel P.¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People’s Republic of China

3. Evotec AG, Essener Bogen 7, 22419 Hamburg, Germany

4. Xenon Pharmaceuticals, Inc., 200-3650 Gilmore Way, Burnaby, British Columbia V5G 4W8, Canada

Funder

Genentech

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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