Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders-Reference-Cited by-同舟云学术

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

Published:2019-04-23 Issue:10 Volume:62 Page:4884-4901
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gurney Mark E.¹,Nugent Richard A.¹,Mo Xuesheng¹,Sindac Janice A.¹^ORCID,Hagen Timothy J.²^ORCID,Fox David³,O’Donnell James M.⁴,Zhang Chong⁴,Xu Ying⁴,Zhang Han-Ting⁵,Groppi Vincent E.⁶,Bailie Marc⁷,White Ronald E.⁸,Romero Donna L.⁹,Vellekoop A. Samuel¹⁰,Walker Joel R.¹⁰^ORCID,Surman Matthew D.¹⁰,Zhu Lei¹⁰,Campbell Robert F.¹⁰

Affiliation:

1. Tetra Discovery Partners, Inc., 38 Fulton Street West, Grand Rapids, Michigan 49503, United States

2. Department of Chemistry and Biochemistry, Northern Illinois University, 1425 West Lincoln Highway, DeKalb, Illinois 60115, United States

3. Beryllium Discovery Corp., 7869 NE Day Road West, Bainbridge Island, Washington 98110, United States

4. Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York 14214-8033, United States

5. Departments of Behavioral Medicine & Psychiatry and Physiology, Pharmacology & Neuroscience, Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, West Virginia 26506, United States

6. Michigan Drug Discovery, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48103, United States

7. INDS Inc., 6111 Jackson Road, Suite 100, Ann Arbor, Michigan 48103, United States

8. White Global Pharma Consultants, 31 Kinglet Drive, South Cranbury, New Jersey 08512, United States

9. Pharma-Vation Consulting, LLC, 1201 Turnberry Ridge Court, Chesterfield, Missouri 63005, United States

10. Albany Molecular Research, Inc., 21 Corporate Circle, Albany, New York 12203, United States

Funder

National Institute of Neurological Disorders and Stroke

National Institute on Aging

NIH Blueprint for Neuroscience Research

Tetra Discovery Partners, Inc.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00193

Reference81 articles.

1. Cyclic AMP Control Measured in Two Compartments in HEK293 Cells: Phosphodiesterase KM Is More Important than Phosphodiesterase Localization

2. Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

3. PDE4D and PDE4B Function in Distinct Subcellular Compartments in Mouse Embryonic Fibroblasts

4. PKA Dynamics in a Drosophila Learning Center: Coincidence Detection by Rutabaga Adenylyl Cyclase and Spatial Regulation by Dunce Phosphodiesterase

5. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

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