Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor

Author:

Zhou Fang1234,Ding Kang1534,Zhou Yiqing67,Liu Yang1,Liu Xiaoyan1,Zhao Fei1,Wu Yiran1,Zhang Xianjun1348,Tan Qiwen1,Xu Fei14,Tan Wenfu9,Xiao Youli63ORCID,Zhao Suwen14ORCID,Tao Houchao1ORCID

Affiliation:

1. iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong New District, Shanghai 201210, China

2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Building 3, Room 426, Shanghai 201203, China

3. University of Chinese Academy of Sciences, No. 19A, Yuquan Road, Beijing 100049, China

4. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China

5. Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

6. CAS Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China

7. School of Biotechnology and Food Engineering, Changshu Institute of Technology, Suzhou, Jiangsu 215500, China

8. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

9. Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Shanghai Municipality

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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