Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo-Reference-Cited by-同舟云学术

Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo

Published:2019-09-18 Issue:5 Volume:63 Page:2229-2239
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Spicer Julie A.¹²^ORCID,Miller Christian K.¹²,O’Connor Patrick D.¹²,Jose Jiney¹²,Giddens Anna C.¹,Jaiswal Jagdish K.¹²,Jamieson Stephen M. F.¹²³,Bull Matthew R.¹²,Denny William A.¹²^ORCID,Akhlaghi Hedieh⁴,Trapani Joseph A.⁴⁵,Hill Geoff R.⁶,Chang Karshing⁶,Gartlan Kate H.⁶

Affiliation:

1. Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

2. Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland 1010, New Zealand

3. Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

4. Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia

5. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia

6. QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia

Funder

Wellcome Trust

Auckland Division of the Cancer Society, New Zealand

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00881

Reference28 articles.

1. The structural basis for membrane binding and pore formation by lymphocyte perforin

2. Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules

3. Perforin and granzymes: function, dysfunction and human pathology

4. Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition

5. Pancreatic Islets Under Attack: Cellular and Molecular Effectors

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