Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)-Reference-Cited by-同舟云学术

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)

Published:2019-03-20 Issue:7 Volume:62 Page:3228-3250
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Watterson Scott H.¹^ORCID,Liu Qingjie¹,Beaudoin Bertrand Myra¹,Batt Douglas G.¹,Li Ling¹,Pattoli Mark A.¹,Skala Stacey¹,Cheng Lihong¹,Obermeier Mary T.¹,Moore Robin¹,Yang Zheng¹,Vickery Rodney¹,Elzinga Paul A.¹,Discenza Lorell¹,D’Arienzo Celia¹,Gillooly Kathleen M.¹,Taylor Tracy L.¹,Pulicicchio Claudine¹,Zhang Yifan¹,Heimrich Elizabeth¹,McIntyre Kim W.¹,Ruan Qian¹,Westhouse Richard A.¹,Catlett Ian M.¹,Zheng Naiyu¹^ORCID,Chaudhry Charu¹,Dai Jun¹^ORCID,Galella Michael A.¹,Tebben Andrew J.¹,Pokross Matt¹,Li Jianqing¹^ORCID,Zhao Rulin¹,Smith Daniel¹,Rampulla Richard¹,Allentoff Alban¹,Wallace Michael A.¹,Mathur Arvind¹,Salter-Cid Luisa¹,Macor John E.¹,Carter Percy H.¹^ORCID,Fura Aberra¹,Burke James R.¹,Tino Joseph A.¹

Affiliation:

1. Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00167

Reference58 articles.

1. Genes on the X chromosome affect development of collagen-induced arthritis in mice

2. Ability of the xid gene to prevent autoimmunity in (NZB X NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA.

3. RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents