Route to Prolonged Residence Time at the Histamine H1 Receptor: Growing from Desloratadine to Rupatadine-Reference-Cited by-同舟云学术

Route to Prolonged Residence Time at the Histamine H1 Receptor: Growing from Desloratadine to Rupatadine

Published:2019-06-20 Issue:14 Volume:62 Page:6630-6644
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bosma Reggie¹,Wang Zhiyong¹,Kooistra Albert J.¹^ORCID,Bushby Nick²,Kuhne Sebastiaan¹,van den Bor Jelle¹,Waring Michael J.³^ORCID,de Graaf Chris¹^ORCID,de Esch Iwan J.¹,Vischer Henry F.¹^ORCID,Sheppard Robert J.⁴,Wijtmans Maikel¹^ORCID,Leurs Rob¹^ORCID

Affiliation:

1. Amsterdam Institute for Molecules, Medicines and Systems, Division of Medicinal Chemistry, Faculty of Science, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

2. Operations, BioPharmaceuticals R&D, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, United Kingdom

3. Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, United Kingdom

4. Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg 431 50, Sweden

Funder

China Scholarship Council

Seventh Framework Programme

European Federation of Pharmaceutical Industries and Associations

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00447

Reference58 articles.

1. Biochemical mechanisms of drug action: what does it take for success?