Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists-Reference-Cited by-同舟云学术

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

Published:2019-12-10 Issue:1 Volume:63 Page:241-259
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Meijer Femke A.¹^ORCID,Doveston Richard G.¹²,de Vries Rens M.J.M.¹,Vos Gaël M.¹,Vos Alex A.A.¹,Leysen Seppe¹,Scheepstra Marcel¹,Ottmann Christian¹^ORCID,Milroy Lech-Gustav¹,Brunsveld Luc¹^ORCID

Affiliation:

1. Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Technische Universiteit Eindhoven, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands

2. Leicester Institute of Structural and Chemical Biology and Department of Chemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.

Funder

European Commission

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01372

Reference52 articles.

1. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

2. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer