Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo-Reference-Cited by-同舟云学术

Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo

Published:2020-02-07 Issue:6 Volume:63 Page:3104-3119
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ju Yuan¹,He Lihui¹,Zhou Yuanzheng¹,Yang Tao¹²,Sun Ke¹,Song Rao¹,Yang Yang¹,Li Chengwei¹³,Sang Zitai⁴,Bao Rui¹,Luo Youfu¹^ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

2. Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China

3. Suzhou Zelgen Biopharmaceuticals Co., Ltd., Kunshan, Jiangsu 215301, China

4. Institute of Life Science, Luoyang Normal University, Luoyang, Henan 471934, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

National Major Scientific and Technological Special Project for ???Significant New Drugs Development???

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01746

Reference53 articles.

1. Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus

2. Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

3. Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence

4. The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes

5. The ClpP Protease of Streptococcus pneumoniae Modulates Virulence Gene Expression and Protects against Fatal Pneumococcal Challenge

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