Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model-Reference-Cited by-同舟云学术

Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model

Published:2020-03-19 Issue:12 Volume:63 Page:6523-6537
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhao Jihui¹²,Cui Rongrong¹³,Wang Lihao⁴,Chen Yingjia¹,Fu Zunyun¹³,Ding Xiaoyu¹,Cui Chen¹,Yang Tianbiao¹,Li Xutong¹,Xu Yuan⁵,Chen Kaixian¹³⁶,Luo Xiaomin¹^ORCID,Jiang Hualiang¹³⁶,Zheng Mingyue¹²^ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China

2. University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing 100049, China

3. College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Qixia District, Nanjing 210023, China

4. Gillings School of Public Health, University of North Carolina at Chapel Hill, 135 Dauer Drive, Chapel Hill, North Carolina 27599, United States

5. Shanghai EnnovaBio Pharmaceuticals Co., Ltd., Room 404, Building 2, Lane 720, Cailun Road, Pudong New Area, Shanghai 200120, China

6. Shanghai Institute for Advanced Immunochemical Studies, and School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China

Funder

National Natural Science Foundation of China

Department of S and T for Social Development

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01895

Reference39 articles.

1. Medicinal chemistry approaches to avoid aldehyde oxidase metabolism

2. A Novel Reaction Mediated by Human Aldehyde Oxidase: Amide Hydrolysis of GDC-0834

3. Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery

4. The two faces of aldehyde oxidase: Oxidative and reductive transformations of 5-nitroquinoline

5. Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015

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