3,5,7-Substituted Pyrazolo[4,3-d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models-Reference-Cited by-同舟云学术

3,5,7-Substituted Pyrazolo[4,3-d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models

Published:2019-04-03 Issue:9 Volume:62 Page:4606-4623
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jorda Radek¹^ORCID,Havlíček Libor²,Šturc Antonín²,Tušková Diana³,Daumová Lenka³,Alam Mahmudul³,Škerlová Jana⁴⁵,Nekardová Michaela⁴⁶^ORCID,Peřina Miroslav¹,Pospíšil Tomáš¹^ORCID,Široká Jitka¹,Urbánek Lubor¹,Pachl Petr⁴,Řezáčová Pavlína⁴⁵,Strnad Miroslav¹,Klener Pavel³,Kryštof Vladimír¹^ORCID

Affiliation:

1. Laboratory of Growth Regulators, Palacký University and Institute of Experimental Botany, The Czech Academy of Sciences, Šlechtitelů 27, 783 71 Olomouc, Czech Republic

2. Isotope Laboratory, Institute of Experimental Botany, The Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic

3. Institute of Pathological Physiology, First Faculty of Medicine, Charles University, 128 53 Prague, Czech Republic

4. Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic

5. Institute of Molecular Genetics, The Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic

6. Faculty of Mathematics and Physics, Charles University in Prague, Ke Karlovu 3, 121 16 Prague 2, Czech Republic

Funder

European Regional Development Fund

Grantov?? Agentura Cesk?? Republiky

Univerzita Palack??ho v Olomouci

Univerzita Karlova v Praze

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00189

Reference60 articles.

1. High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma

2. Current and emerging treatment options for mantle cell lymphoma

3. New targeted therapies for malignant lymphoma based on molecular heterogeneity

4. Cyclin-dependent kinases

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