Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs)-Reference-Cited by-同舟云学术

Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs)

Published:2019-04-25 Issue:10 Volume:62 Page:5132-5147
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Reilly Sean W.¹^ORCID,Riad Aladdin A.¹,Hsieh Chia-Ju¹^ORCID,Sahlholm Kristoffer¹,Jacome Daniel A.²,Griffin Suzy³,Taylor Michelle³,Weng Chi-Chang¹,Xu Kuiying¹,Kirschner Nathan¹,Luedtke Robert R.³,Parry Christopher⁴,Malhotra Shipra⁴,Karanicolas John⁴^ORCID,Mach Robert H.¹^ORCID

Affiliation:

1. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

2. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, United States

3. Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, United States

4. Program in Molecular Therapeutics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, United States

Funder

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00412

Reference53 articles.

1. Current drug treatments targeting dopamine D3 receptor

2. Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis