Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II-Reference-Cited by-同舟云学术

Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II

Published:2019-08-13 Issue:17 Volume:62 Page:8164-8177
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Van Zandt Michael C.¹^ORCID,Jagdmann G. Erik¹,Whitehouse Darren L.¹,Ji Minkoo¹,Savoy Jennifer¹,Potapova Olga²,Cousido-Siah Alexandra³,Mitschler Andre³,Howard Eduardo I.⁴,Pyle Anna Marie²,Podjarny Alberto D.³

Affiliation:

1. New England Discovery Partners, 23 Business Park Drive, Branford, Connecticut 06405, United States

2. Department of Molecular, Cellular and Developmental Biology and Department of Chemistry, Howard Hughes Medical Institute, Yale University, 219 Prospect Street, New Haven, Connecticut 06511, United States

3. Department of Integrative Biology, IGBMC, CNRS, INSERM, Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France

4. Instituto de Fisica de Liquidos y Sistemas Biologicos (IFLYSIB), CONICET, Calle 59 Numero 789, 1900 La Plata, Buenos Aires, Argentina

Funder

Howard Hughes Medical Institute

Institut National de la Sant? et de la Recherche M?dicale

Universit? de Strasbourg

Centre National de la Recherche Scientifique

H?pitaux Universitaires de Strasbourg

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00931

Reference32 articles.

1. Recent advances in arginine metabolism: roles and regulation of the arginases

2. Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

3. l-Arginine and its metabolites in kidney and cardiovascular disease

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5. Arginase as a target for treatment of myocardial ischemia-reperfusion injury

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