Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2
Author:
Affiliation:
1. School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, U.K.
2. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.
Funder
Merck Sharp and Dohme
Ministry of Education
Scottish Universities Life Science Alliance
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00162
Reference57 articles.
1. Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond
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3. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs
4. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death
5. Sphingosine-1-Phosphate Phosphatases
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