An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors-Reference-Cited by-同舟云学术

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An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors

Published:2019-11-27 Issue:24 Volume:62 Page:11348-11358
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Wen,Sviripa Vitaliy M.^ORCID,Kril Liliia M.,Yu Tianxin,Xie Yanqi,Hubbard W. Brad^ORCID,Sullivan Patrick G.,Chen Xi,Zhan Chang-Guo^ORCID,Yang-Hartwich Yang¹,Evers B. Mark^ORCID,Spear Brett T.,Gedaly Roberto,Watt David S.,Liu Chunming^ORCID

Affiliation:

1. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, LSOG 209, 375 Congress Avenue, New Haven Connecticut 06510, United States

Funder

National Center for Advancing Translational Sciences

National Cancer Institute

National Center for Research Resources

U.S. Department of Defense

American Cancer Society

College of Medicine, University of Kentucky

College of Pharmacy, University of Kentucky

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01685

Reference38 articles.

1. A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers

2. Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

3. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

4. Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors

5. Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling

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1. Synthesis and anti-proliferative effect of novel 4-Aryl-1, 3-Thiazole-TPP conjugates via mitochondrial uncoupling process;Bioorganic Chemistry;2024-09

2. Mitochondrial function and gastrointestinal diseases;Nature Reviews Gastroenterology & Hepatology;2024-05-13

3. Inhibition of Carbohydrate Metabolism Potentiated by the Therapeutic Effects of Oxidative Phosphorylation Inhibitors in Colon Cancer Cells;Cancers;2024-04-02

4. Zebrafish drug screening identifies Erlotinib as an inhibitor of Wnt/β-catenin signaling and self-renewal in T-cell acute lymphoblastic leukemia;Biomedicine & Pharmacotherapy;2024-01

5. Synthesis and Anti-Proliferative Effect of Novel 4-Aryl-1, 3-Thiazole-Tpp Conjugates Via Mitochondrial Uncoupling Process;2024

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