Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators-Reference-Cited by-同舟云学术

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Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators

Published:2019-05-10 Issue:10 Volume:62 Page:5063-5079
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boulton Stephen,Selvaratnam Rajeevan¹,Ahmed Rashik^ORCID,Van Katherine,Cheng Xiaodong²,Melacini Giuseppe^ORCID

Affiliation:

1. Department of Laboratory Medicine, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 2C4, Canada

2. Department of Integrative Biology and Pharmacology and Texas Therapeutics Institute, McGovern Medical School, University of Texas Health Science Center, Houston, Texas 77030, United States

Funder

Institute of Genetics

National Institute of Allergy and Infectious Diseases

Natural Sciences and Engineering Research Council of Canada

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00258

Reference90 articles.

1. High-throughput assays for promiscuous inhibitors

2. A High-Throughput Screen for Aggregation-Based Inhibition in a Large Compound Library

3. A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

4. A Specific Mechanism of Nonspecific Inhibition

5. New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

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