Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region

Published:2019-10-24 Issue:21 Volume:62 Page:9680-9690
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

McGowan David C.¹^ORCID,Balemans Wendy¹,Embrechts Werner¹^ORCID,Motte Magali²,Keown Jeremy R.³^ORCID,Buyck Christophe¹,Corbera Jordi⁴,Funes Mario⁴,Moreno Laura⁴,Cooymans Ludwig¹,Tahri Abdellah¹,Eymard Julien⁵,Stoops Bart¹,Strijbos Rudy⁶,Van den Berg Joke¹,Fodor Ervin⁷,Grimes Jonathan M.³⁸,Koul Anil¹,Jonckers Tim H. M.¹,Raboisson Pierre¹,Guillemont Jérôme²

Affiliation:

1. Janssen Pharmaceutica, N.V., Turnhoutseweg 30, 2340 Beerse, Belgium

2. Janssen-Cilag, Campus de Maigremont BP615, F-27106 Val de Reuil, Cedex, France

3. Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom

4. Eurofins Villapharma Research, S.L., Avda. Isaac Peral, Parque Tecnológico de Fuente Álamo, Ctra. El Estrecho-Lobosillo, 30320 Murcia, Spain

5. Novalix (site Janssen-Cilag), Campus de Maigremont BP615, F-27106 Val de Reuil, Cedex, France

6. Charles River Laboratories Beerse, Turnhoutseweg 30, 2340 Beerse, Belgium

7. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom

8. Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, United Kingdom

Funder

Medical Research Council

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01091

Reference42 articles.

1. The Center for Disease Control. https://www.cdc.gov/flu/keyfacts.htm (accessed May 19, 2019).

2. NIH RePORT, https://report.nih.gov/NIHfactsheets/ViewFactSheet.aspx?csid=133 (accessed May 19, 2019).

3. OECD website (accessed June 11, 2019), https://data.oecd.org/healthcare/influenza-vaccination-rates.htm.

4. Influenza

5. Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

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