Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis-Reference-Cited by-同舟云学术

Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis

Published:2019-12-20 Issue:4 Volume:63 Page:1528-1543
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rappas Mathieu¹,Ali Ammar A. E.¹,Bennett Kirstie A.¹,Brown Jason D.¹,Bucknell Sarah J.¹,Congreve Miles¹^ORCID,Cooke Robert M.¹,Cseke Gabriella¹,de Graaf Chris¹,Doré Andrew S.¹,Errey James C.¹,Jazayeri Ali¹,Marshall Fiona H.¹,Mason Jonathan S.¹,Mould Richard¹,Patel Jayesh C.¹,Tehan Benjamin G.¹,Weir Malcolm¹,Christopher John A.¹^ORCID

Affiliation:

1. Sosei Heptares, Steinmetz Building, Granta Park, Cambridge CB21 6DG, U.K.

Funder

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01787

Reference75 articles.

1. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior