New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

Author:

Malek Rim12,Arribas Raquel L.34,Palomino-Antolin Alejandra456,Totoson Perle7,Demougeot Celine7,Kobrlova Tereza89,Soukup Ondrej89,Iriepa Isabel,Moraleda Ignacio,Diez-Iriepa Daniel10,Godyń Justyna11,Panek Dawid11,Malawska Barbara11ORCID,Głuch-Lutwin Monika11,Mordyl Barbara11,Siwek Agata11,Chabchoub Fakher2,Marco-Contelles José10ORCID,Kiec-Kononowicz Katarzyna11,Egea Javier456,de los Ríos Cristóbal34ORCID,Ismaili Lhassane1ORCID

Affiliation:

1. Neurosciences Intégratives et Cliniques EA 481, Pôle de Chimie Organique et Thérapeutique, Université Bourgogne Franche-Comté, UFR Santé, 19, Rue Ambroise Paré, F-25000 Besançon, France

2. Laboratory of Applied Chemistry: Heterocycles, Lipids and Polymers, University of Sfax, B. P 802, 3000 Sfax, Tunisia

3. Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, C/Diego de León, 62, 28006 Madrid, Spain

4. Instituto Teofilo Hernando, Universidad Autónoma de Madrid, C/Arzobispo Morcillo, 4, 28029 Madrid, Spain

5. Molecular Neuroinflammation and Neuronal Plasticity Laboratory, Research Unit, Hospital Universitario Santa Cristina, 28009 Madrid, Spain

6. Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, 28006 Madrid, Spain

7. EA4267 PEPITE, Université Bourgogne Franche-Comté, F-25030, Besançon, France

8. Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, CZ-500 01 Hradec Kralove, Czech Republic

9. Biomedical Research Center, University Hospital CZ-500 05 Hradec Kralove, Czech Republic

10. Laboratory of Medicinal Chemistry, IQOG, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain

11. Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland

Funder

Fundaci?n Mutua Madrile?a

Uniwersytet Jagiellonski Collegium Medicum

European Regional Development Fund

European Cooperation in Science and Technology

Instituto de Salud Carlos III

Regional Council of Franche-Comt?

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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