Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease

Author:

Abás Sònia1,Rodríguez-Arévalo Sergio1,Bagán Andrea1,Griñán-Ferré Christian2,Vasilopoulou Foteini2,Brocos-Mosquera Iria3,Muguruza Carolina3ORCID,Pérez Belén4,Molins Elies5ORCID,Luque F. Javier6ORCID,Pérez-Lozano Pilar7ORCID,de Jonghe Steven8ORCID,Daelemans Dirk8,Naesens Lieve8,Brea José9,Loza M. Isabel9,Hernández-Hernández Elena10,García-Sevilla Jesús A.10,García-Fuster M. Julia10,Radan Milica11,Djikic Teodora11,Nikolic Katarina11,Pallàs Mercè2ORCID,Callado Luis F.3,Escolano Carmen1ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain

2. Pharmacology Section, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institut de Neurociències, University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain

3. Department of Pharmacology, and Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, University of the Basque Country, UPV/EHU, E-48940 Leioa, Bizkaia, Spain

4. Department of Pharmacology, Therapeutic and Toxicology, Autonomous University of Barcelona, E-08193 Barcelona, Spain

5. Institut de Ciència de Materials de Barcelona (CSIC), Campus UAB, E-08193 Cerdanyola, Spain

6. Department of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), and Institute of Theoretical and Computational Chemistry (IQTCUB), University of Barcelona, E-08921 Santa Coloma de Gramanet, Spain

7. Unit of Pharmaceutical Technology, Pharmacy and Pharmaceutical Technology, and Physical Chemistry Department, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain

8. Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium

9. Innopharma screening platform, BioFarma research group, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain

10. IUNICS University of the Balearic Islands (UIB), and Health Research Institute of the Balearic Islands (IdISBa), Cra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain

11. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia

Funder

Generalitat de Catalunya

Ministerio de Economi ?a y Competitividad of Spain

Ministry of Science and Technological Development of the Republic of Serbia

Basque Government

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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