Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165-Reference-Cited by-同舟云学术

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165

Published:2019-07-18 Issue:20 Volume:62 Page:8973-8995
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wrobleski Stephen T.^ORCID,Moslin Ryan^ORCID,Lin Shuqun,Zhang Yanlei,Spergel Steven^ORCID,Kempson James^ORCID,Tokarski John S.,Strnad Joann,Zupa-Fernandez Adriana,Cheng Lihong,Shuster David,Gillooly Kathleen,Yang Xiaoxia,Heimrich Elizabeth,McIntyre Kim W.,Chaudhry Charu,Khan Javed,Ruzanov Max,Tredup Jeffrey,Mulligan Dawn,Xie Dianlin,Sun Huadong,Huang Christine,D’Arienzo Celia,Aranibar Nelly,Chiney Manoj,Chimalakonda Anjaneya,Pitts William J.,Lombardo Louis,Carter Percy H.^ORCID,Burke James R.,Weinstein David S.

Funder

Bristol-Myers Squibb

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00444

Reference88 articles.

1. The regulation of JAKs in cytokine signaling and its breakdown in disease

2. Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases

3. JAK Kinases in Health and Disease: An Update

4. Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases

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