Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases
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Published:2020-02-19
Issue:11
Volume:63
Page:5697-5722
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ISSN:0022-2623
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Container-title:Journal of Medicinal Chemistry
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language:en
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Short-container-title:J. Med. Chem.
Author:
Mainolfi Nello1, Ehara Takeru1, Karki Rajeshri G.1ORCID, Anderson Karen1, Mac Sweeney Aengus2ORCID, Liao Sha-Mei1, Argikar Upendra A.1ORCID, Jendza Keith1, Zhang Chun1, Powers James1, Klosowski Daniel W.1, Crowley Maura1, Kawanami Toshio1, Ding Jian1, April Myriam1, Forster Cornelia1, Serrano-Wu Michael1, Capparelli Michael1, Ramqaj Rrezarta2, Solovay Catherine1, Cumin Frederic2, Smith Thomas M.1, Ferrara Luciana1, Lee Wendy1, Long Debby1, Prentiss Melissa1, De Erkenez Andrea1, Yang Louis1, Liu Fang1, Sellner Holger2, Sirockin Finton2ORCID, Valeur Eric2, Erbel Paulus2, Ostermeier Daniela2, Ramage Paul2, Gerhartz Bernd2, Schubart Anna2, Flohr Stefanie2, Gradoux Nathalie2, Feifel Roland2, Vogg Barbara2, Wiesmann Christian2, Maibaum Jürgen2, Eder Jörg2, Sedrani Richard2, Harrison Richard A.2, Mogi Muneto1, Jaffee Bruce D.1, Adams Christopher M.1ORCID
Affiliation:
1. Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States 2. Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland
Funder
Novartis Institutes for BioMedical Research Inc.
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Cited by
24 articles.
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