Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

Author:

Popova Gergana1ORCID,Ladds Marcus J. G. W.12,Johansson Lars3,Saleh Aljona4,Larsson Johanna5,Sandberg Lars56,Sahlberg Sara Häggblad7,Qian Weixing8,Gullberg Hjalmar7,Garg Neeraj5,Gustavsson Anna-Lena3,Haraldsson Martin3,Lane David1,Yngve Ulrika5,Lain Sonia12

Affiliation:

1. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Solna, Stockholm, Sweden

2. SciLifeLab, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Tomtebodavägen 23, SE-171 21 Solna, Stockholm, Sweden

3. Chemical Biology Consortium Sweden, SciLifeLab, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 21 Stockholm, Sweden

4. SciLifeLab, Drug Discovery and Development Platform, ADME of Therapeutics Facility, Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden

5. SciLifeLab, Drug Discovery and Development Platform, Department of Medicinal Chemistry, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden

6. SciLifeLab, Drug Discovery and Development Platform, Department of Organic Chemistry, Stockholm University, Box 1030, SE-171 21 Solna, Stockholm, Sweden

7. SciLifeLab, Drug Discovery and Development Platform, Department of Biochemistry and Biophysics, Stockholm University, SE-171 21 Solna, Stockholm, Sweden

8. Chemical Biology Consortium Sweden, Laboratories for Chemical Biology Umeå, Umeå University, SE-901 87 Umeå, Sweden

Funder

Science for Life Laboratory

Vetenskapsrådet

Cancerfonden

Karolinska Institutet

Barncancerfonden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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