Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1–XPF-Reference-Cited by-同舟云学术

Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1–XPF

Published:2019-08-01 Issue:17 Volume:62 Page:7684-7696
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Elmenoufy Ahmed H.¹²,Gentile Francesco³,Jay David⁴,Karimi-Busheri Feridoun⁴,Yang Xiaoyan⁴,Soueidan Olivier M.¹,Weilbeer Claudia¹,Mani Rajam S.⁴,Barakat Khaled H.⁵,Tuszynski Jack A.³⁴,Weinfeld Michael⁴,West Frederick G.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada

2. Department of Pharmaceutical Chemistry, College of Pharmacy, Misr University for Science and Technology, P.O. Box 77, 6th of October City 12568, Egypt

3. Department of Physics, University of Alberta, Edmonton, Alberta T6G 2E1, Canada

4. Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta T6G 1Z2, Canada

5. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2H1, Canada

Funder

Alberta Cancer Foundation

University of Alberta

Alberta Innovates

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00326

Reference47 articles.

1. Xeroderma Pigmentosum Group F Caused by a Defect in a Structure-Specific DNA Repair Endonuclease

2. Inhibition of the ERCC1–XPF structure-specific endonuclease to overcome cancer chemoresistance

3. DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy

4. Recruitment and positioning determine the specific role of the XPF ‐ ERCC 1 endonuclease in interstrand crosslink repair

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