Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease-Reference-Cited by-同舟云学术

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Published:2020-03-05 Issue:6 Volume:63 Page:3066-3089
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Harrison Justin R.¹,Sarkar Sandipan²,Hampton Shahienaz¹^ORCID,Riley Jennifer¹,Stojanovski Laste¹,Sahlberg Christer³,Appelqvist Pia³,Erath Jessey⁴,Mathan Vinodhini²,Rodriguez Ana⁴,Kaiser Marcel⁵⁶,Pacanowska Dolores Gonzalez⁷,Read Kevin D.¹^ORCID,Johansson Nils Gunnar³,Gilbert Ian H.¹^ORCID

Affiliation:

1. Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, United Kingdom

2. Syngene International Ltd, Biocon Park, SEZ, Bommasandra Industrial Area, Phase-IV, Bommasandra-Jigani Link Road, Bangalore 560 099, India

3. Medivir, Lunastigen 7, 141 44 Huddinge, Sweden

4. New York University School of Medicine, 430 East 29th Street, Alexandria Center West Tower, Room 511, Lab 524, New York, New York 10010, United States

5. Swiss Tropical and Public Health Institute (Swiss TPH), Socinstrasse 57, Basel CH-4051, Switzerland

6. University of Basel, Petersplatz 1, Basel CH-4003, Switzerland

7. Instituto de Parasitología y Biomedicina “López-Neyra”, Avda. Conocimiento S/N, Parque Tecnológico Ciencias de la Salud18016 Armilla, Granada Spain

Funder

FP7 Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01852

Reference27 articles.

1. Chagas Disease: From Discovery to a Worldwide Health Problem

2. Quantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases

3. Challenges and recent progress in drug discovery for tropical diseases