Syntheses and Evaluation of New Bisacridine Derivatives for Dual Binding of G-Quadruplex and i-Motif in Regulating Oncogene c-myc Expression-Reference-Cited by-同舟云学术

Syntheses and Evaluation of New Bisacridine Derivatives for Dual Binding of G-Quadruplex and i-Motif in Regulating Oncogene c-myc Expression

Published:2020-08-12 Issue:17 Volume:63 Page:9136-9153
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kuang Guotao¹,Zhang Meiling¹,Kang Shuangshuang¹,Hu Dexuan¹,Li Xiaoya¹,Wei Zuzhuang¹,Gong Xue¹,An Lin-Kun¹^ORCID,Huang Zhi-Shu¹^ORCID,Shu Bing¹²,Li Ding¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Sun Yat-sen University, 132 Waihuan East Road, Guangzhou 510006, P. R. China

2. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. China

Funder

Guangdong Science and Technology Department

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Youth Innovation Talents Project of Colleges and Universities in Guangdong Province

Guangdong Provincial Key Laboratory of Construction Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01917

Reference54 articles.

1. The spliceosome is a therapeutic vulnerability in MYC-driven cancer

2. Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics

3. Inhibition of c-Myc expression accounts for an increase in the number of multinucleated cells in human cervical epithelial cells

4. Function of the c-Myc Oncogenic Transcription Factor

5. Transcriptional Amplification in Tumor Cells with Elevated c-Myc

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