Serendipitous Discovery of Leucine and Methionine Depletion Agents during the Search for Polyamine Transport Inhibitors
Author:
Affiliation:
1. College of Medicine, University of Central Florida 12722 Research Parkway Orlando, Florida 32827, United States
Funder
Florida Department of Health
College of Medicine, University of Central Florida
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00568
Reference36 articles.
1. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
2. Modulation of cellular function by polyamines
3. Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors.
4. The roles of the polyamines, putrescine, spermidine, and spermine in normal and malignant tissues
5. Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells
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