Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma-Reference-Cited by-同舟云学术

Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma

Published:2019-08-15 Issue:17 Volume:62 Page:7769-7787
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Munck af Rosenschöld Magnus,Johannesson Petra,Nikitidis Antonios,Tyrchan Christian,Chang Hui-Fang,Rönn Robert¹,Chapman Dave,Ullah Victoria,Nikitidis Grigorios,Glader Pernilla,Käck Helena^ORCID,Bonn Britta,Wågberg Fredrik,Björkstrand Eva¹,Andersson Ulf,Swedin Linda,Rohman Mattias,Andreasson Theresa,Bergström Eva Lamm,Jiang Fanyi,Zhou Xiao-Hong,Lundqvist Anders J.,Malmberg Anna,Ek Margareta,Gordon Euan,Pettersen Anna^ORCID,Ripa Lena^ORCID,Davis Andrew M.

Affiliation:

1. Orexo AB, Virdings allé 32A, SE-75450 Uppsala, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00555

Reference94 articles.

1. Prevalence and management of severe asthma in primary care: an observational cohort study in Sweden (PACEHR)

2. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

3. High levels of urinary leukotriene E4 excretion in steroid treated patients with severe asthma

4. Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children

Cited by 16 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. An Analysis of Successful Hit-to-Clinical Candidate Pairs;Journal of Medicinal Chemistry;2023-05-24

2. Treatment of allergy: Overview of synthetic anti-allergy small molecules in medicinal chemistry;European Journal of Medicinal Chemistry;2023-03

3. Lead Optimisation: What You Should Know!;The Handbook of Medicinal Chemistry;2023-02-03

4. Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics;Annual Review of Pharmacology and Toxicology;2023-01-20

5. Fe(OTf)₃-catalyzed annulation of α,β-unsaturated ketoxime acetates with enaminones for the synthesis of functionalized 2,4-diarylpyridines;Organic Chemistry Frontiers;2023