Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analogue with Enhanced Stability-Reference-Cited by-同舟云学术

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Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analogue with Enhanced Stability

Published:2019-12-05 Issue:24 Volume:62 Page:11437-11443
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zheng Nan¹,Karra Prasoona²,VandenBerg Michael A.³,Kim Jin Hwan¹,Webber Matthew J.³^ORCID,Holland William L.²,Chou Danny Hung-Chieh¹^ORCID

Affiliation:

1. Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, United States

2. Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah 84112, United States

3. Department of Chemical Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States

Funder

American Diabetes Association

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01589

Reference42 articles.

1. The disulphide bonds of insulin

2. Evolution of Insulin: From Human to Analog

3. Pursuit of a perfect insulin

4. Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.

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3. Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity;Communications Chemistry;2023-11-21

4. From Natural Insulin to Designed Analogs: A Chemical Biology Exploration;ChemBioChem;2023-10-06

5. Semisynthesis of A6–A11 lactam insulin;Journal of Peptide Science;2023-09-11

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