Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders-Reference-Cited by-同舟云学术

Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders

Published:2019-09-27 Issue:21 Volume:62 Page:9471-9487
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Jiuling,Li Yangbing,Aguilar Angelo,Liu Zhaomin,Yang Chao-Yie^ORCID,Wang Shaomeng^ORCID

Funder

U.S. Department of Health and Human Services

University of Michigan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00846

Reference48 articles.

1. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

2. PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery

3. Waste disposal—An attractive strategy for cancer therapy

4. Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy

5. Targeted protein degradation by PROTACs

Cited by 116 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Inducing or enhancing protein-protein interaction to develop drugs: Molecular glues with various biological activity;European Journal of Medicinal Chemistry;2024-11

2. Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs;ACS Chemical Biology;2024-09-12

3. Advances in analytical technologies for emerging drug modalities and their separation challenges in LC-MS systems;Journal of Chromatography A;2024-09

4. Schisandrol B inhibits calcification of aortic valve by targeting p53 related inflammatory and senescence;Biomedicine & Pharmacotherapy;2024-09

5. Confounding Factors in Targeted Degradation of Short-Lived Proteins;ACS Chemical Biology;2024-07-03