CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success?
Author:
Affiliation:
1. School of Pharmacy, Lebanese American University, P.O. Box 36, Byblos, Lebanon
2. Drug Discovery and Development, University of South Australia Cancer Research Institute, Adelaide, SA 5000, Australia
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01985
Reference122 articles.
1. Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery
2. Inhibitors of cyclin-dependent kinases as cancer therapeutics
3. MAT1 (‘menage à trois’) a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.
4. Reciprocal Activation by Cyclin-Dependent Kinases 2 and 7 Is Directed by Substrate Specificity Determinants outside the T Loop
5. Repression of TFIIH Transcriptional Activity and TFIIH-Associated cdk7 Kinase Activity at Mitosis
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