Dual-Acting Cholinesterase–Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo

Author:

Scheiner Matthias1,Dolles Dominik1,Gunesch Sandra1,Hoffmann Matthias1,Nabissi Massimo2,Marinelli Oliviero2,Naldi Marina3,Bartolini Manuela3,Petralla Sabrina4,Poeta Eleonora4,Monti Barbara4,Falkeis Christina5,Vieth Michael5,Hübner Harald6,Gmeiner Peter6ORCID,Maitra Rangan7ORCID,Maurice Tangui8,Decker Michael1ORCID

Affiliation:

1. Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, Am Hubland, 97074 Würzburg, Germany

2. School of Pharmacy, University of Camerino, Via Madonna delle Carceri 9, 62032 Camerino, Italy

3. Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy

4. Department of Pharmacy and Biotechnology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy

5. Pathology, Clinical Center Bayreuth, Preuschwitzer Straße 101, 95445 Bayreuth, Germany

6. Medicinal Chemistry, Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen, Germany

7. Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States

8. MMDN, University of Montpellier, INSERM, EPHE, UMR-S1198, 34095 Montpellier, France

Funder

Bundesministerium f?r Bildung und Forschung

Elitenetzwerk Bayern

Deutscher Akademischer Austauschdienst

Campus France

Ministero dell?Istruzione, dell?Universit? e della Ricerca

Deutsche Forschungsgemeinschaft

Studienstiftung des Deutschen Volkes

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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