Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt—Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy-Reference-Cited by-同舟云学术

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt—Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

Published:2019-10-22 Issue:21 Volume:62 Page:9931-9946
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Marcoux David¹^ORCID,Duan James J.-W.¹^ORCID,Shi Qing¹^ORCID,Cherney Robert J.¹,Srivastava Anurag S.¹,Cornelius Lyndon¹,Batt Douglas G.¹,Liu Qingjie¹,Beaudoin-Bertrand Myra¹,Weigelt Carolyn A.¹,Khandelwal Purnima¹,Vishwakrishnan Sureshbabu²,Selvakumar Kumaravel²,Karmakar Ananta²^ORCID,Gupta Arun Kumar²,Basha Mushkin²,Ramlingam Sridharan²,Manjunath Naveen²,Vanteru Sridhar²,Karmakar Sukhen²,Maddala Nageswara²,Vetrichelvan Muthalagu²^ORCID,Gupta Anuradha²^ORCID,Rampulla Richard A.¹,Mathur Arvind¹,Yip Shiuhang¹,Li Peng¹,Wu Dauh-Rurng¹,Khan Javed¹,Ruzanov Max¹,Sack John S.¹,Wang Jinhong¹,Yarde Melissa¹,Cvijic Mary Ellen¹,Li Sha¹,Shuster David J.¹,Borowski Virna¹,Xie Jenny H.¹,McIntyre Kim W.¹,Obermeier Mary T.¹,Fura Aberra¹,Stefanski Kevin¹,Cornelius Georgia¹,Hynes John¹,Tino Joseph A.¹,Macor John E.¹,Salter-Cid Luisa¹,Denton Rex¹,Zhao Qihong¹,Carter Percy H.¹^ORCID,Dhar T. G. Murali¹^ORCID

Affiliation:

1. Research and Development, Bristol-Myers Squibb, 3551 Lawrenceville Rd, Princeton, New Jersey 08540, United States

2. Department of Discovery Synthesis, Biocon Bristol-Myers Squibb Research Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bengaluru 560099, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01369

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