4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain
Author:
Affiliation:
1. Drug Discovery and Preclinical Development, Carrer Baldiri Reixac, ESTEVE Pharmaceuticals SA, 4-8 Parc Científic de Barcelona, 08028 Barcelona, Spain
2. Carrer Baldiri Reixac, Enantia, SL, 10 Parc Científic de Barcelona, 08028 Barcelona, Spain
Funder
European Regional Development Fund
Ministerio de Econom?a y Competitividad
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01256
Reference58 articles.
1. Treatment of chronic non-cancer pain
2. Pain as a global public health priority
3. Opioids in neuropathic pain: clues from animal studies
4. A Brief History of the Opioid Epidemic and Strategies for Pain Medicine
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