Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway
Author:
Affiliation:
1. GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00348
Reference47 articles.
1. Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises
2. Targeting the phosphoinositide 3-kinase pathway in cancer
3. Targeting the PI3K pathway in cancer: are we making headway?
4. Targeting RTK Signaling Pathways in Cancer
5. How Insulin Receptor Substrate Proteins Regulate the Metabolic Capacity of the Liver - Implications for Health and Disease
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