Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells

Author:

Denèfle Thomas12,Pramil Elodie123,Gómez-Morales Luis124,Levasseur Mikail D.12ORCID,Lardé Eva12,Newton Clara12,Herry Kenny5,Herbi Linda3,Lamotte Yann5,Odile Estelle12,Ancellin Nicolas5,Grondin Pascal5,Martinez-Torres Ana-Carolina4,Viviani Fabrice5,Merle-Beral Hélène3,Lequin Olivier1ORCID,Susin Santos A.3,Karoyan Philippe12678ORCID

Affiliation:

1. Sorbonne Université, Ecole Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM, 75005 Paris, France

2. Sorbonne Université, Ecole Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM, Site OncoDesign, 25-27 Avenue du Québec, 91140 Les Ulis, France

3. Cell Death and Drug Resistance in Lymphoproliferative Disorders Team, Centre de Recherche des Cordeliers, INSERM UMRS 1138, 75006 Paris, France

4. Laboratory of Immunology and Virology, Autonomous University of Nuevo Leon, 66451 San Nicolas de los Garza, NL, Mexico

5. OncoDesign, 25 Avenue du Québec, 91140 Les Ulis, France

6. SiRIC CURAMUS (CANCER UNITED RESEARCH ASSOCIATING MEDICINE, UNIVERSITY & SOCIETY, Site de Recherche Intégrée sur le Cancer) IUC, AP-HP.6, Sorbonne Université 75005 Paris, France

7. Kayvisa AG, Industriestrasse, 44, 6300 Zug, Switzerland

8. Kaybiotix GmbH, Zugerstrasse 32, 6340 Baar, Switzerland

Funder

Institut National Du Cancer

SATT Lutech

DGRTT, Sorbonne Universit?

ECOS nord

CURAMUS

Labex Michem

IPV program

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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